Nicolas Cage is Charlie Kaufman, a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman, Orlean's book, become strangely intertwined as each one's search for passion collides with the others'.

Adam, a lonely man with Asperger's Syndrome, develops a relationship with his upstairs neighbor, Beth.

Ann Harding plays a lovely but somewhat naive young woman who goes on a European vacation after winning a lottery. Swept off her feet by charming Basil Rathbone, Harding finds herself married before she is fully able to grasp the situation. Slowly but surely, Rathbone's loving veneer crumbles; when he casually asks Harding to sign a document turning her entire fortune over to him, she deduces that her days are numbered.

Ted Kramer is a career man for whom his work comes before his family. His wife Joanna cannot take this anymore, so she decides to leave him. Ted is now faced with the tasks of housekeeping and taking care of himself and their young son Billy.

An assassin is shot by her ruthless employer, Bill, and other members of their assassination circle – but she lives to plot her vengeance.

Dave Lizewski is an unnoticed high school student and comic book fan who one day decides to become a super-hero, even though he has no powers, training or meaningful reason to do so.