Childhood chums Rocky Sullivan and Jerry Connelly grow up on opposite sides of the fence: Rocky matures into a prominent gangster, while Jerry becomes a priest, tending to the needs of his old tenement neighborhood.

Bob Adams, ace newsreel cameraman, is told by his boss, "Get the picture---we can't screen alibis." He heads for Samari, a desert hot-bed of tribal unrest in Africa, to do just that, which includes getting footage of El Kadar, bandit and rebel leader. He gets his pictures but only after a romance with the Colonel's daughter Pamela, saving his wimpy, hacked-off brother Don from being a dupe of the gun-runners, and run-ins with spies and throat-cutting tribesman. For a finale, he saves the British Army.

Ann Harding plays a lovely but somewhat naive young woman who goes on a European vacation after winning a lottery. Swept off her feet by charming Basil Rathbone, Harding finds herself married before she is fully able to grasp the situation. Slowly but surely, Rathbone's loving veneer crumbles; when he casually asks Harding to sign a document turning her entire fortune over to him, she deduces that her days are numbered.

Duke and Jeanie Benson, an outlaw couple hiding out under assumed names. Duke realizes that he has a winning sweepstake ticket and will win $150,000 if he can cash it in without getting apprehended

A dark and stormy night in a drugstore. The druggist mixes a potion and falls asleep. The skull-and-crossbones on the bottle comes to life and drips the potion on the druggist.

Holmes, retired to Sussex, is drawn into a last case when his arch enemy Moriarty arranges with an American gang to kill one John Douglas, a country gentleman with a mysterious past. Holmes' methods baffle Watson and Lestrade, but his results astonish them. In a long flashback, the victim's wife tells the story of the sinister Vermissa Valley.

Hard-boiled newspaper reporter Larry Doyle (Robert Armstrong) goes a bit too far in celebrating a work bonus and wakes up on a train bound for St. Louis with only a buck on his person. To remedy the problem, Doyle pawns the revolver he's carrying. When the gun is subsequently used in a murder, Doyle's problems only multiply. In the meantime, he's also fallen in love with a comely stranger (Maxine Doyle) he convinced to impersonate his wife.

The gang decides to build their own fire engine.

Philo Vance, accompanied by his prize-losing Scottish terrier, investigates the locked-room murder of a prominent and much-hated collector whose broken Chinese vase provides an important clue.