A dark and stormy night in a drugstore. The druggist mixes a potion and falls asleep. The skull-and-crossbones on the bottle comes to life and drips the potion on the druggist.

In 18th-century Romania, after spending much of her life in a traveling circus, human-vampire hybrid Rayne escapes and plots to take down her father, Kagan, the evil vampire king. When she's discovered by three vampire hunters, she manages to convince them to spare her life and join her cause. But slaying a vampire as powerful as Kagan will be no easy task.

In an effort to get enough money to afford expensive treatment for her gravely ill American husband, a retired German entertainer returns to the cabaret, gaining fame as Blonde Venus and unknowingly catching the eye of a wealthy politician.

The generous John Jarndyce, struggling with his own past, and his two young wards Richard and Ada, are all caught up, like Lady Dedlock, in the infamous case of Jarndyce vs. Jarndyce, which will make one of them rich beyond imagination if it can ever be brought to a conclusion. As Tulkinghorn digs deeper into Lady Dedlock's past, he unearths a secret that will change their lives forever, and which is almost as astounding as the final outcome of the Jarndyce case.