A dark and stormy night in a drugstore. The druggist mixes a potion and falls asleep. The skull-and-crossbones on the bottle comes to life and drips the potion on the druggist.

Hard-boiled newspaper reporter Larry Doyle (Robert Armstrong) goes a bit too far in celebrating a work bonus and wakes up on a train bound for St. Louis with only a buck on his person. To remedy the problem, Doyle pawns the revolver he's carrying. When the gun is subsequently used in a murder, Doyle's problems only multiply. In the meantime, he's also fallen in love with a comely stranger (Maxine Doyle) he convinced to impersonate his wife.

In an effort to get enough money to afford expensive treatment for her gravely ill American husband, a retired German entertainer returns to the cabaret, gaining fame as Blonde Venus and unknowingly catching the eye of a wealthy politician.

An American missionary is gradually seduced by a courtly warlord holding her in Shanghai.

A detective tries to figure out who killed a man who predicted his own death.