A sailor takes an American businessman and his girlfriend to an island where the businessman wants to build a resort. Soon a weird voodoo couple show up and warn them of bad things that are going to happen. It doesn't take long for the zombies to show up and start chowing down on human flesh.

In 1974, a family of six was brutally murdered. A year later, George and Kathy Lutz and their children move into the site of the horrific event, which is haunted by a murderous presence.

After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.

The plot takes place in New York, and in the present. In a Hotel called "Quicky" a professor blackmails a student of his into having sex with him. But when the professor puts on a condom, the carnivorous condom bites off his penis and disappears. Detective Mackaroni who gets the case thinks that the college girl just bit off her teacher's penis! Mackaroni goes to the motel himself to check out the crime scene, in the lobby he finds a gigolo named Bill and he asks him to follow him to crime room, there the two men attempt to have sex when they are suddenly interrupted by the attack of a killer condom.