In this highly influential silent horror film, the mysterious Count Orlok (Max Schreck) summons Thomas Hutter (Gustav von Wangenheim) to his remote Transylvanian castle in the mountains. The eerie Orlok seeks to buy a house near Hutter and his wife, Ellen (Greta Schroeder). After Orlok reveals his vampire nature, Hutter struggles to escape the castle, knowing that Ellen is in grave danger. Meanwhile Orlok's servant, Knock (Alexander Granach), prepares for his master to arrive at his new home.

A man and wife are terrorized by Mad Scientist Dr. Callistratus who was executed but has returned to life with a heart transplant. Along with his crippled assistant Carl, the 'anemic' Mad Scientist, believed to be a vampire, conducts blood deficiency research on the inmates of a prison hospital for the criminally insane to sustain his return to life.

A naïve young girl desperate to fit in with her new boyfriend's tightly knit crew learns that membership may be deadly. Upon arriving at a party with her new boyfriend, Shawn, desperate-to-fit-in newcomer Debbie learns that the friends have formed a mysterious brotherhood nicknamed "The Murder Club." As Debbie accepts her invitation to join the mysterious club, a murderer who seems to take the group's name to heart begins killing off members one by one.