At first, Dr. Sidney Schaefer feels honored and thrilled to be offered the job of the President's Analyst. But then the stress of the job and the paranoid spies that come with a sensitive government position get to him, and he runs away. Now spies from all over the world are after him, either to get him for their own side or to kill him and prevent someone else from getting him.

Mild-mannered mystery writer D. H. Mercer has become so immersed in his material that his creation, hard-boiled private eye Biff Deegan, constantly appears to him as a hallucination. Intent on getting rid of Biff, and replacing him with a more civilized detective, Mercer soon finds himself in a genuine mystery involving art fraud, murder, and a beautiful lady in peril.