Right before his daughter's wedding, a mild-mannered foot doctor discovers that his new in-laws are international smugglers.

For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.

Between his tax problems and his legal battle with his wife for the custody of his daughter, these are hard times for the action movie star who finds that even Steven Seagal has pinched a role from him! This fictionalized version of Jean-Claude Van Damme returns to the country of his birth to seek the peace and tranquility he can no longer enjoy in the United States, but inadvertently gets involved in a bank robbery with hostages.

The lives of two families, one white American, one native American, become mingled through the momentous events of American expansion, between 1825 and 1890.