Never Give a Sucker an Even Break is a 1941 film about a man who wants to sell a film story to Esoteric Studios. On the way he gets insulted by little boys, beaten up for ogling a woman, and abused by a waitress. W. C. Fields' last starring role in a feature-length film.

Successful movie director John L. Sullivan, convinced he won't be able to film his ambitious masterpiece until he has suffered, dons a hobo disguise and sets off on a journey, aiming to "know trouble" first-hand. When all he finds is a train ride back to Hollywood and a beautiful blonde companion, he redoubles his efforts, managing to land himself in more trouble than he bargained for when he loses his memory and ends up a prisoner on a chain gang.