Ethan Hunt and his IMF team embark on their most dangerous mission yet: To track down a terrifying new weapon that threatens all of humanity before it falls into the wrong hands. With control of the future and the world's fate at stake and dark forces from Ethan's past closing in, a deadly race around the globe begins. Confronted by a mysterious, all-powerful enemy, Ethan must consider that nothing can matter more than his mission—not even the lives of those he cares about most.

When an IMF mission ends badly, the world is faced with dire consequences. As Ethan Hunt takes it upon himself to fulfill his original briefing, the CIA begin to question his loyalty and his motives. The IMF team find themselves in a race against time, hunted by assassins while trying to prevent a global catastrophe.

Ethan and team take on their most impossible mission yet—eradicating 'The Syndicate', an International and highly-skilled rogue organization committed to destroying the IMF.