A man and wife are terrorized by Mad Scientist Dr. Callistratus who was executed but has returned to life with a heart transplant. Along with his crippled assistant Carl, the 'anemic' Mad Scientist, believed to be a vampire, conducts blood deficiency research on the inmates of a prison hospital for the criminally insane to sustain his return to life.

In the year 2012, the 3rd great war comes to an end. The war claims no victors, but both sides succeed in executing their chemical warfare campaigns. The result is over 3 billion deaths. Over ninety-eight percent of the male survivors are rendered sterile. Human reproduction is realized by means of cloning. The first strand of clones are harvested in December of 2012 and received with overwhelming success. It was not until nineteen years later that the first problems arose.

In an effort to get enough money to afford expensive treatment for her gravely ill American husband, a retired German entertainer returns to the cabaret, gaining fame as Blonde Venus and unknowingly catching the eye of a wealthy politician.

A naïve young girl desperate to fit in with her new boyfriend's tightly knit crew learns that membership may be deadly. Upon arriving at a party with her new boyfriend, Shawn, desperate-to-fit-in newcomer Debbie learns that the friends have formed a mysterious brotherhood nicknamed "The Murder Club." As Debbie accepts her invitation to join the mysterious club, a murderer who seems to take the group's name to heart begins killing off members one by one.

The generous John Jarndyce, struggling with his own past, and his two young wards Richard and Ada, are all caught up, like Lady Dedlock, in the infamous case of Jarndyce vs. Jarndyce, which will make one of them rich beyond imagination if it can ever be brought to a conclusion. As Tulkinghorn digs deeper into Lady Dedlock's past, he unearths a secret that will change their lives forever, and which is almost as astounding as the final outcome of the Jarndyce case.