Guido Anselmi, a film director, finds himself creatively barren at the peak of his career. Urged by his doctors to rest, Anselmi heads for a luxurious resort, but a sorry group gathers—his producer, staff, actors, wife, mistress, and relatives—each one begging him to get on with the show. In retreat from their dependency, he fantasizes about past women and dreams of his childhood.

Fellini discusses his views of making motion pictures and his unorthodox procedures. He seeks inspiration in various out of the way places. During this film viewers go with him to the Colisseum at night, on a subway ride past Roman ruins, to the Appian Way, to a slaughterhouse, and on a visit to Marcello Mastroianni's house. Fellini also is seen in his own office interviewing a series of unusual characters seeking work or his help.